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Research
 

Devices

Cell Permeabilization: We have shown that a jet of non-thermal plasma and inert gas can temporarily permeabilize adherent cells.

1. Chouinard-Pelletier G, Leduc M, Guay D, Coulombe S, Leask RL, Jones EA. (2012) Use of inert gas jets to measure the forces required for mechanical gene transfection. Biomed Eng Online 2012;11:67.
2. Leduc M, Guay D, Coulombe S, Leask RL. (2010) Effects of non-thermal plasmas on DNA and mammalian cells, Plasma Processes and Polymers 2010;7(11) 899-909. Leduc M.,
3. Coulombe S, Leask RL (2009), Atmospheric pressure plasma jet deposition of patterned polymer films for cell culture applications. IEEE transactions on plasma science  37(6): 927-933
4. Leduc M, Guay D
, Leask RL, Coulombe S (2009). Cell permeabilization using non-thermal plasma. New Journal of Physics 11: 115021

Endovascular Devices: We design and test catheter based devices such as coronary stents, pediatric stents, transcatheter pulmonary aorta shunts and vena cava filters.

1. Mejia J., Mongrain M., Ruzzeh B., Leask RL and Bertrand OF (2009), Evaluation of the Effect of Stent Strut Profile on Shear Stress Distribution Using Statistical Moments. Biomed Eng OnLine  Apr 30;8:8. 2.
2. Faik I.
,Mongrain R., Leask RL., Rodes-Cabau J., Larose E., Bertrand O. (2007) Time-dependent 3D simulations of the hemodynamics in a stented coronary artery. Biomed. Mater. 2;S28-S37.
3. Mongrain R., Faik I., Leask R. L, Rodes-Cabau J., Larose E., Bertrand O.  (2007) Effects of Diffusion Coefficients and Struts Apposition Using Numerical Simulations for Drug Eluting Coronary Stents.  J Biomech Eng. October 129;1-10.
4. U.S. Patent Pending: Baylis Medical Corporation, Mongrain R., Leask RL. “Stent”, Patent Application #60/808126, 22 May 2006t
5. Leask RL, Johnston KW, Ojha M. Hemodynamic effects of clot entrapment in the TrapEase inferior vena cava filter.J Vasc Interv Radiol. 2004 May;15(5):485-90.
6. Leask RL, Johnston KW, Ojha M. In vitro hemodynamic evaluation of a Simon nitinol vena cava filter: possible explanation of IVC occlusion.J Vasc Interv Radiol. 2001 May;12(5):613-8.